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After pooling together 11 articles for the meta-analysis, an overall picture emerged.
Short-acting statins are “significantly more effective” in lowering LDL (the “bad” cholesterol) levels when they are administered in the evening, rather than the morning, the researchers found.
Long-acting statins, on the other hand, had a “nearly equivalent efficacy irrespective of timing of administration during the day, with the exception of a small but statistically significant effect” on LDL levels.
Short acting statins include pravastatin, simvastatin, lovastatin, and fluvastatin with half-lives of two to five hours.
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