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What have experts said about the study?
Speaking to Medical News Today, Professor Julie Williams of Cardiff University said: “I would not go far as saying it’s causing the sex difference, but it may be contributing, but there’s a bit more work that needs to be done to really stand that up. But it is a very interesting and novel finding.”
Professor Williams added the findings “were of great interest to the field” and highlighted the numerous studies which had come before this research set. However, she acknowledged that the USP11 gene had not yet been looked at.
Meanwhile, Professor Bart De Strooper added: “[I]t should be noticed that evidence is largely gathered in a preclinical setting, in models of the disease such as cell cultures and mouse models, but that the experiments are sound and indeed support the overall conclusions of the paper.
“I would say that this work deserves further follow-up by drug developers to see whether the X-linked ubiquitin peptidase can be targeted in the context of Alzheimer’s and frontotemporal disease.”
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