The huge blaze has ignited a majority of the industrial unit on High Street North as up to 70 firefighters and 10 fire engines were on the scene.
A number of gas cylinders have exploded due to the heat.
The London Fire Brigade (LFB) were called shortly before 9.51pm.
One Twitter user said: “Kwikfit tyre shop on fire nearby in Manor Park.
“Lots of thick black smoke, terrible smell, tons of smoke, lots of fire sirens.”
The LFB have said in a statement: “The single storey unit was badly damaged by fire.
“People from neighbouring properties have been evacuated.
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“Fire crews from East Ham and surrounding fire stations.
“The cause of the fire is under investigation.”
More to follow…