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In a study published in the National Library of Health, ibuprofen toxicity and liver disease were further analysed.
The study reported a case regarding a 59-year-old woman who was treated with ibuprofen (600 mg three times daily) for hip pain and developed jaundice and fatigue five days later.
She was admitted to a referral hospital and the medication was stopped.
Laboratory results showed marked elevations in serum aminotransferase levels and serum bilirubin of 20 mg/dL (Table).
She continued to do poorly and developed ascites and renal dysfunction.
She underwent successful liver transplantation 10 weeks after onset.
The liver showed submassive hepatic necrosis.
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